Purpose: We report a patient with severe multi-organ dysfunction of unknown origin who presented with bilateral orbital and chorioretinal manifestations that led to the diagnosis of Erdheim-Chester Disease (ECD).Observations: ECD is a rare, histiocytic, proliferative disorder characterized by multi-systemic organ involvement that has historically l
Abstract Background Orchids produce a colorless protocorm by symbiosis with fungi upon seed germination.For mass production of orchids, the prevailing approaches are both generation of protocorm-like bodies (PLBs) from callus and multiplication of adventitious buds on inflorescence.However, somaclonal variations Wafers occur during micropropagation
Our ability to discover effective drug combinations is limited, in part by insufficient understanding of how the Plant transcriptional response of two monotherapies results in that of their combination.We analyzed matched time course RNAseq profiling of cells treated with single drugs and their combinations and found that the transcriptional signat
MotivationExperiments in which the effect of combined manipulations is compared with the effects of their pure ZOOT COMB SYSTEM constituents have received a great deal of attention.Examples include the study of combination therapies and the comparison of double and single knockout model organisms.Often the effect of the combined manipulation is not